Gene name:
SLC22A18 (BWR1A;BWSCR1A;HET;IMPT1;ITM;ORCTL2;SLC22A1L;TSSC5) ;
Protein name:
Solute carrier family 22 member 18 ;
Alternative:
Efflux transporter-like protein ;Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein ;Organic cation transporter-like protein 2 (ORCTL-2) ;Imprinted multi-membrane-spanning polyspecific transporter-related protein 1 ;Tumor-suppressing STF cDNA 5 protein ;Solute carrier family 22 member 1-like ;p45-Beckwith-Wiedemann region 1 A (p45-BWR1A) ;Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RNF167.
Function:
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.
Subcellular Location:
Apical cell membrane
Multi-pass membrane protein
Localized at the apical membrane surface of renal proximal tubules.
Protein Attributes:
50:
MQGARAPRDQ | GRSPGRMSAL | GRSSVILLTY | VLAATELTCL | FMQFSIVPYL |
100:
SRKLGLDSIA | FGYLQTTFGV | LQLLGGPVFG | RFADQRGARA | ALTLSFLAAL |
150:
ALYLLLAAAS | SPALPGVYLL | FASRLPGALM | HTLPAAQMVI | TDLSAPEERP |
200:
AALGRLGLCF | GVGVILGSLL | GGTLVSAYGI | QCPAILAALA | TLLGAVLSFT |
250:
CIPASTKGAK | TDAQAPLPGG | PRASVFDLKA | IASLLRLPDV | PRIFLVKVAS |
300:
NCPTGLFMVM | FSIISMDFFQ | LEAAQAGYLM | SFFGLLQMVT | QGLVIGQLSS |
350:
HFSEEVLLRA | SVLVFIVVGL | AMAWMSSVFH | FCLLVPGLVF | SLCTLNVVTD |
400:
SMLIKAVSTS | DTGTMLGLCA | SVQPLLRTLG | PTVGGLLYRS | FGVPVFGHVQ |
424:
VAINTLVLLV | LWRKPMPQRK | DKVR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human Solute carrier family 22 member 18
ELISA Kit for Human Solute carrier family 22 member 18
ELISA Kit for Human Solute carrier family 22 member 18
CLIA Kit for Human Solute carrier family 22 member 18
CLIA Kit for Human Solute carrier family 22 member 18
CLIA Kit for Human Solute carrier family 22 member 18
Polyclonal Antibody for Human Solute carrier family 22 member 18
Polyclonal Antibody for Human Solute carrier family 22 member 18
Polyclonal Antibody for Human Solute carrier family 22 member 18
Monoclonal Antibody for Human Solute carrier family 22 member 18
Monoclonal Antibody for Human Solute carrier family 22 member 18
Monoclonal Antibody for Human Solute carrier family 22 member 18
Protein for Human Solute carrier family 22 member 18
Protein for Human Solute carrier family 22 member 18
Protein for Human Solute carrier family 22 member 18
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5."
Lee M.P.
,
Reeves C.
,
Schmitt A.
,
Su K.
,
Connors T.D.
,
Hu R.J.
,
Brandenburg S.
,
Lee M.J.
,
Miller G.
,
Feinberg A.P.
Cancer Res.58:4155-4159(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLN-309;VARIANT LUNG CANCER PHE-233
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
"Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain."
Cooper P.R.
,
Smilinich N.J.
,
Day C.D.
,
Nowak N.J.
,
Reid L.H.
,
Pearsall R.S.
,
Reece M.
,
Prawitt D.
,
Landers J.
,
Housman D.E.
,
Winterpacht A.
,
Zabel B.U.
,
Pelletier J.
,
Weissman B.E.
,
Shows T.B.
,
Higgins M.J.
Genomics49:38-51(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANT GLN-12
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue :
Placenta .
5.
"Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples."
Schwienbacher C.
,
Sabbioni S.
,
Campi M.
,
Veronese A.
,
Bernardi G.
,
Menegatti A.
,
Hatada I.
,
Mukai T.
,
Ohashi H.
,
Barbanti-Brodano G.
,
Croce C.M.
,
Negrini M.
Proc. Natl. Acad. Sci. U.S.A.95:3873-3878(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANTS THR-6 AND GLN-12; CYS-86;TISSUE SPECIFICITY
6.
"Monoallelic expression of the gene encoding a human efflux transporter like protein (HET), on chromosome 11p15.5."
Chen P.
,
Shen W.
,
Karnik P.
Submitted (1998-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLN-12
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLN-12
tissue :
Placenta .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RNF167